Studies on teratogenic and maternal effects of Trichothecene (TCT) extracted from Fusarium and Trichoderma culture on pregnant Albino Mice

Mycotoxins (frequently referred to as secondary metabolites of toxigenic fungi) are commonly found in foodstuffs and essential because their association with disease. The current study investigated the teratogenic potential characteristics T-2 trichothecenes mycotoxins produced by Fusarium Trichoderma, which reportedly toxic humans animals pregnant mice. toxin is a cytotoxic fungal metabolite that belongs trichothecene mycotoxin family. T2 was administered intraperitoneally Pregnant females single injection at levels 50, 75,100, 125 ppb on one gestation days 7-11 during pregnancy period. A significant reduction mean fetal body weight various malformations (i.e., external skeletal) were observed following maternal exposure T2. This first report implicate this T -2 teratogen our region. Our revealed ppm enough cause abortion mice within several days. Keywords: toxin, trichothecenes, mycotoxins, fungi,